A routine missing persons case for Private Investigator Rory Mack Steele turns into terror for America when the deadliest disease mankind has ever known is resurrected and unleashed as a weapon of mass destruction to reshape the future of the world. Framed and now pursued by the authorities, Rory must find some way to fight back against the formidable foe responsible, and save billions around the globe from dying a painful, agonizing death in the Fire Plague.